OraSIL™ Wound Wash Irrigant 10ppm

OraSIL™ Wound Wash Irrigant 10ppm is the Worlds first comprehensive drug free, Wound Healing NanoSilver Wound Wash Irrigant specifically formulated to safely and effectively irrigate, disinfect and debride colonized tissues and biofilms in surgical sites, while reducing post-operative complications through superior wound healing and anti-inflammatory action.

OraSIL™ Wound Wash Irrigant 10ppm reduces pain, swelling, infection and delayed wound healing caused by Surgical Site Infections (“SSI’s)  before, during and after a diverse range of dental procedures

  • Disinfects by actively targeting pathogenic bacteria and yeast without harming probiotic bacteria.
  • Provides additional antimicrobial and wound healing support in conjunction with the OraSIL Wound Healing Hydrogel
  • Safe on all intr-oral tissues and effective at helping to eliminate granulation tissue components during wound healing
  • Helps improve clinical outcomes  and reduces post op. complications
  • Ideal for extractions, laser therapy, partial and full thickness flaps and grafts
  • Excellent for non surgical periodontal and denture therapies
  • Compatible with all surgical materials, hemostatics, adhesives and biologic materials
  • Non Staining. Contains natural ingredients.
  • No Contraindications. Safe to swallow.

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PRODUCT CODE: ORAWWI10ppm80Z, ORAWWI10ppm160Z, ORAWWI10ppm320Z

SIZES: 8 oz, 16 oz, 32 oz bottles

OraSIL™ Wound Wash Irrigant 10ppm product is designed to help disinfect a surgical site, medical device insertion site or donor /recipient graft site, and to increase wound healing. It is ideal for disinfecting, irrigating, and debriding extraction sites, gingival grafts, ginigivectomies and gingivoplasties, SRP procedures, boney ostectomies, teeth and bone sectioning, apicoectomies and biopsies. And, tissue lesions that include ulcers, denture sores, mucositis, stomatitis and treatment protocols for patients suffering from candida infections. The OraSIL™ Wound Wash Irrigant 10ppm can be used as an alternative to Saline to rehydrate both Bone Allografts and Collagen Membranes and can be applied during surgery or afterwards at a post op care appointment if and when debridement of the surgical site is required.  When required, OraSIL™ Wound Wash Irrigant 10ppm should be followed with OraSIL™ Wound Healing HydroGel, providing further antimicrobial, wound healing benefit for the patient.

Q1: What intra-oral Dental procedures can I use the OraSIL™ Wound Wash Irrigant 10ppm for?

A:

  • To help hydrate the tissues, Remove blood and debris and for improved visualization of the surgical field.
  • During ALL Oral surgical procedures involving full thickness flaps, boney ostectomies and sectioning of teeth.
  • To help disrupt and remove Bacterial Biofilms.
  • Under split or full thickness flaps in periosseous surgery and on exposed root surfaces.
  • As an Oral rinse to treat the mucoperiosteal tissues under a partial or complete denture infected with Candida albicans;
  • To Rehydrate Collagen Membranes and Bone Allograft Particulates.
  • As a wash in Endontic surgery – apicoectomies etc
  • As a Restorative rinse to wash away etchant gels and disinfect any exposed Dentine.
  • Can be placed in the DWUL bottle and sprayed into the cavity preparation using the tri-syringe or hand piece.
  • As an Irrigating solution in Laser therapy for Soft Tissue Recontouring eg.  ginigivectomies / gingivoplasties.
  • Non Surgical Periodontal Therapy – as the Irrigating solution in the cavitron or piezo electric water resevoirs.
  • As an Endodontic Irrigant solution.
  • To soak/disinfect and store a dental appliance; – MADs, Ortho retainers, CATs, Nightguards, orthotics and Periodontal Trays/Splints.

Q2: What is the chemical makeup of OraSIL™ Wound Wash Irrigant 10ppm?

A:  OraSIL™ Wound Wash Irrigant 10ppm contains only one ingredient: 10 ppm Nano Silver in Deionized water. It is a Prescription strength wound wash irrgant and wound treatment solution which is capable of removing Polymicrobial Biofilms associated with a many bacteria commonly found in the mouth.

Q3: Does OraSIL™ Wound Wash Irrigant 10ppm contain glycerin and or any pe troleum by-products?

A:  No.

Q4:  What is the Recommend application time for the OraSIL™ Wound Wash Irrigant 10ppm?

A: Apply to affected mucosal tissues and or device with a liberal coating as many times a day as you would like until infection and inflammation has resolved. Essential- ly, the OraSIL™ Wound Wash Irrigant 10ppm is made up of ultra-fine Nanoparticles in highly purifed water so it is safe and non toxic to use when ingested.  It can sit on the affected tissues for as long as is required without casuing any harm to the surround ing tissues.

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LIMITATIONS & CHALLENGES WITH CURRENT WOUND CLEANSING SOLUTIONS ……..

Wound irrigation is the steady flow of a solution across an open wound surface to achieve wound hydration, to remove deeper debris, and to assist with the visual examination. The irrigation solution is meant to remove cellular debris and surface pathogens contained in wound exudates or residue from topically applied wound care products. Compared to swabbing or bathing, wound irrigation is considered to be the most consistently effective method of wound cleansing.*

  • Ennis et al, Trauma and Wound Care, 2004, Pge 291-307.

The wound wash market is dominated by Sterile Normal Saline which is a Neutral Buffered solution of .9% Sodium Chloride. After Saline, Sterile water is the most commonly used product becasue both are Isotonic and non toxic. These irrigating solutions are typically  used for cleansing a surgical site or a healing wound. Due to their physiologic nature, Saline and Sterile water are always safe to use in wounds. However, they do not contain any surfactants (found in commercial wound cleansers) which are more effective at lifting bacteria and debris from the wound. Saline also does not do well cleaning in dirty necotic wounds. Normal saline also does not contain any preservatives to prevent microbialgrowth. Studies have shown that bacterial growth in saline may be present within 24 hours of opening the container so Sterile Normal Saline should be discarded after as little as 24 hours after opening. Some Dentists / Surgeons prefer to use an “off-label” Antibiotic rinse, however, this method has never been widely adopted because of the inherent risk of developing Anitbiotic resistance and it is expensive.

There are several commercially available Wound Cleanser products for irrigating wounds BUT NONE OF THEM are effective at killing bacteria at concentrations that are safe to healing tissue – cytotoxicity is a major concern. For this reason the Agency for Healthcare Policy and Research (“AHCPR”) guidelines discourage the use of antiseptic solutions as wound irrigants such as povidone iodine, isopropyl alcohols, polyhexanide, hydrogen peroxide, or sodium hypochlorite as they can injure surgerized tissues. The AHCPR recommends avoiding their use in all but the most contaminated wounds. The use of Antibiotic lavages and topical steroid rinses are also no longer in favour.

Commercial Wound Cleansing Solutions are designed specifically to remove or soften necrotic tissue and debris. Most are also non-toxic to healthy tissue and cells. They often come in spray application bottles which are designed to allow safe cleansing of the wound bed without undue pressure. After cleansing the wound, the surrounding skin is usually dabbed dry with a sterile gauze pad or sponge.

Wound Cleansing Solutions:

Most commercial wound cleansers contain preservatives to retard the growth of bacteria, molds, and fungi. This extends the product shelf life but can be hazardous to ones health.

Constant Clens is a commercial Wound Cleanser manufactured by the Kendall Company which contains surfactants that help lift bacteria and cellular debris out of wounds with minimal force. These products may enhance cleansing in wounds with adherent cellular debris or in dirty, necrotic wounds.

Hydrogen Peroxide is Cytotoxic to healthy cells and granulating tissues. Its effervescent cleansing action helps to lift debris from the wound surface when used at full strength. If used full strength, irrigation with normal saline after use is recommended. Hydrogen Peroxide is NOT effective at killing bacteria and should not be used on wounds with sinus tracts. Again, the use of Hydrogen Peroxide is to be avoided in all but the most contaminated wounds.

Sodium Hypochlorite (Dakin Solution) is Cytotoxic to healthy cells and granulating tissues. The AHCPR guidelines discourage the use of Sodium hypochlorite because it is not effective at killing bacteria at concentrations that are safe to healing tissue. Dakin Solution does have a Bactericidal effect against most organisms commonly found in open wounds and is frequently used in pressure ulcers with necrotic tissue to help control infection.  Dakin Solution is occasionally used over cancerous growths to control bacteria and minimize odor but should not be used for periods longer than 7-10 day. Again, the use of Sodium Hypochlorite is to be avoided in all but the most contaminated wounds.

Povidone Iodine is cytotoxic to healthy cells and granulating tissues and is costly. It is a broad spectrum antimicrobial effective against a variety of pathogens including Staphylococcus aureus but at the 1% concentration commonly used to cleanse wounds  its’ efficacy is questionable.  Povidone Iodine also dries and discolors skin and may cause local irritation to the periwound skin and it use should be avoided in all but the most contaminated wounds.

Pluronic F-68 (Shur-Clens) is manufactured by Spectrum Lab Products,Inc. The active ingredient in this wound wash irrigant is a synthetic chemcial named Polyoxyethylene-polyoxypropylene block copolymer which has no antibacterial activity. This chemcial is a surfactant and contains specific ingredients (Ethylene oxide; 1,4-Dioxane) that the State of California (under proposition 65) says cause reproductive harm, birth defects and cancer. Shur-Clens may cause skin irritation in sensitive individuals. It can also be absorbed through the skin.

Prontosan by BBraun Medical is an antiseptic solution which contains 0.1% undecylenamidopropyl betaine plus 0.1% polyaminopropyl biguanide (polyhexanide [PHMB]) in purified water.  Antimicrobial in its effect but, as a chemical antiseptic it has the potential for allergic reactions as reported in a meeting of the European Academy of Allergy and Clinical Immunology (“EAACI”) in a Food Allergy and Ananphylaxis Meeting “(FAAM”) in Rome Italy 2016, Oct 13-16 by Fabrícia Carolino, Josefina R. Cernadas.

NONE of the aforementioned products including Sterile water or Normal Saline are classified by the FDA as Antimicrobial Preservatives.

NONE of the aforementioned wound wash irrigants / cleansers can legitimately make Antimicrobial claims while simultaneously having any substantial wound healing capabilities.

Of the aforementioned products only (Prontosan) has any real capacity to effectively remove Polymicrobial Biofilms but once again it is a synthetic chemical which has no wound healing capabilities and it is not an Antimicrobial Preservative.

The use of silver ions as a chemotherapeutic wound dressing have a long clinical history of success but, the challenge with ionic silver wound wash solutions is that the silver ion only has a plus one charge (missing one electron) so when it targets a bacterial cell wall and grabs an electron it becomes “neutralralized’ – it then looses its charge and any residual ability to affect the microrganism. This means that the concentration of charged ionic silver particles reqired to provide antibacterial activity must be extremely high.  Additionally, ionic silver has not been proven effective against polymicrobial biofilms and so if you cannot remove/irradiacte the intracellular matrix which ‘houses’ multiple bacterial and fungal strains then you cannot effectively disinfect and remove the source of the infection.

For these reasons, there are only a few wound cleansing solutions which contain ionic silver. The most common is a Topical Silver Sulfadiazine solution which has lost its significance based on recommendations to avoid the topical use of chemotherapeutics, its cytotoxicity and its risk of absorptive side effects.

For much the same reasons, 3 Meta-analyses performed by Cochrane et al., * came to the following conclusions about ionic silver: “Silver [Ionic] can inhibit wound secretion and odor, and some studies showed a promotion of wound healing”. A recent meta-analysis of clinical trials over the last 15 years shows 39 clinical trials on the subject of [ionic] silver inwound treatment. In 28 of the 39 controlled studies, positive aspects were described for wounds, such as accelerated wound healing and bacterial reduction as well as positive aspects in quality of life or pain reduction. On the basis of an expert recommendation, the use of [ionic] Silver in the treatment of critically colonized or infected wounds, as well as in the case of a detected MDRO (Multi Drug Resistant Organisms), was recommended for a maximum of 14 days.

* Dissemond, Böttrich, Braunwarth, Hilt, Wilken, Münter: Evidenz von Silber in der Wundbehandlung – MetaAnalyse der klinischen Studien von 2000– 2015. J Dtsch Dermatol Ges 2017;15:524– 536.

* Vermeulen H, van Hattem JM, Storm-Versloot MN, Ubbink DT: Topical silver for treating infected wounds. Cochrane Database Syst Rev 2007;24:CD005486.

* Storm-Versloot MN, Vos CG, Ubbink DT, Vermeulen H: Topical silver for preventing wound infection. Cochrane DatabaseSyst Rev 2010;17:CD006478.

The aforementioned products are unable to perform with the same level of efficacy and performance as the OraSIL™ Wound Wash Irrigant 10ppm Nanotechnology product.

INTRODUCING a Unique NanoMetallic Silver Tretrahedal Tetraoxide technology…..

Under Scanning Electron Microscope (“SEM”) the crystalline lattice ‘shell’ or ‘oxide layer’ which surrounds the solid Nanometallic core of our OraSIL product contains up to 20,000 highly charged multivalent particles of Ag2O2 and Ag4O4 on its surface. This highly reactive silver oxide layer provides for a brut force, attack on surrounding microoganisms and is why the OraSIL Nanoparticles are so highly effective at killing bacteria. Comparing NanoSilver to Ionic Silver is like comparing a ‘gattling gun’ to a ‘pea shooter’. Remember that when u are dealing with ionic silver you are dealing with “one and done” – when you are dealing with OraSIL NanoSilver you are dealing with a sustained brut force attack.

Until recently, bacteriocidal Wound Wash Irrigant solutions with proven wound healing, anti-inflammatory and pain reducing capabilities simply did not exist. A true bacteriocidal irrigant should be capable of killing MRSA, VRE and CRE, Candida albicans, Candida auris with at least a 4 log reduction, as well as a wide array of oral bacteria and their associated biofilms.  Until the development of the OraSIL™ Wound Wash Irrigant 10ppm, these two features; wound healing and disinfectants had remained mutally exclusive.

The Scientific advantages of NanoSilver in Dentistry has been well established in the peer reviewed Literature**. Addressing the BioFilm issue has also become both a major problem and focus in Clinical Dentistry.

** Silver NanoPaticles in Dentistry –  A review of 155 peer reviewed articles, Dental Materials Volume 33, Issue 10, October 2017, Pages 1110-1126

This specific NanoSilver in ultra-pure deionized water, has been found to be completely safe for human ingestion/absorption and inhalation. In fact, it was recently tested in the largest human clinical trial on the saftey, efficacy and human ingestion of NanoSilver. The results of this human clinical trial has been published in a 3 separate PubMed reports.  (Please refer to the Research Appendices tab under the “Science of Nanotechnology” heading).

The OraSIL™ Wound Wash Irrigant contains 10 ppm NanoSilver in Deionized Water and DOES NOT contain any chemical Preservatives, Phthalates or Sulphates.

There are numerous in-vitro studies which have shown the superior efficacy and performance of NanoSilver over ionic silver especially when it comes to killing micro-organisms and eradicating Biofilms. If you can’t remove/irradiacte the intracellular matrix which houses multiple bacterial and fungal strains then you can’t effectively disinfect and remove the source of the infection.

In one study, the 10ppm version of the OraSIL™ NanoSilver described below, was found to be up 10x more effective that ionic silver products at 3000 ppm concentration!

INTRODUCING a unique NanoMetallic Silver Tretrahedal Tetraoxide technology…..

OraSIL™ Wound Wash Irrigant 10ppm is a powerful wound healing, Disinfectant NanoSilver based solution containing 10ppm NanoSilver in highly purified water. This unique product is capable of providing proven Disinfection and Removal of Polymicrobial BioFilms in medical device insertion sites and surgical incisive wounds. The OraSIL™ Wound Wash Irrigant 10ppm also allows for faster healing with less inflammation and pain.

The OraSIL™ Wound Wash Irrigant 10ppm can be flushed underneath a partial or full thickness flap or into a fresh extraction socket using a syringe similar to a Monoject to help speed up healing and reduce the risk of post op surgical site infections (“SSI”).  Similarily, the OraSIL™ Wound Wash Irrigant 10ppm can also be used to disinfect a partial or complete denture when the patient is suffering from a Candida infection or denture stomatitis. The OraSIL™ Wound Wash Irrigant 10ppm can also be applied over any surgical site/sutures or into a dry socket. During Non Surgical Periodontal therapy the OraSIL™ Wound Wash Irrigant 10ppm can be used to not only irrigate the gingival tissues via ultrasonic instrumentation or manual irrigation but, it can also be used to help remove stain, odor and bacterial buildup on the periodontal tray.

The addition of the NanoSilver makes the OraSIL™ Wound Wash Irrigant 10ppm unique because Multiple in vitro Rapid Challenge Bactieral Tests (against more than 25 of the most common oral bacteria) have demonstrated an ability to kill these oral bacteria without the use of Antibiotics. In combination with Antibiotics we have peer reviewed published data that shows that the OraSIL™ NanoSilver is synergistic and potentiating with 19 different classes of Aminoglycosides (Please Refer to De Souza,Mehta and Leavitt, Current Science Vol 91, Nos. 7, Oct 10, 2006 Article in Scientific Publications Section below]. 

We also have extensive in-vivo human clinical data utilizing literally hundreds of Microbe Link Dx Oral DNA tests which have been performed on patients who have undergone Non Surgical Periodntal Therpay with OraSIL™ Wound Wash Irrigant 10ppm. The results before, during and after Periodontal treatment clearly indicate the ability of the OraSIL™ Wound Wash Irrigant 10ppm to help dramatically reduce bacterial bio-burdens well below the critical threshold levels of up to 11 of the most common periodontal pathogens. For further details please refer to the “Resources/Education/Clinical Protocols/VeraSIL Periodontal Therpay”.

The Scientific advantages of NanoSilver in Dentistry has been well established in the peer reviewed Literature*. Addressing the BioFilm issue has become both a major problem and focus in Clinical Dentistry.

* Silver NanoParticles in Dentistry –  A review of 155 peer reviewed articles, Dental Materials Volume 33, Issue 10, October 2017, Pages 1110-1126

OraSIL™ Wound Wash Irrigant 10ppm is the Worlds FIRST Wound Healing, Disinfectant Wound Wash Irrigant with the following Features and Benefits.

  • Only solid NanoSilver Particle coated with a multi-valent crystalline lattice coating of Ag202 and Ag404.
  • Helps decrease Inflammation due to the Wound Healing, Anti-inflammatory properties of NanoSilver.
  • Meets FDA USP 51 Guidelines / Standard for Antimicrobial Preservative according to CFR 21 Part 58.
  • Preferentially target / kill pathogenic microorganisms without harming probiotic bacteria.
  • Independent studies have shown SilverSol Technology to be up to 10x more effective than products containing up to 3,000ppm silver.
  • Proven to erradiacte Polymicrobial Biofilms associated with many oral bacteria.
  • Rinsing effectively reduces the SSI Rate before surgical wound closure and after surgical management of contaminated wounds.*
  • Synergistic and potentiating with 19 different classes of Aminoglycoside Antibioitcs**
  • Antimicrobial efficacy against  top 15 most common microorganisms found in the mouth.
  • Contains no phenols, iodofors, or any other chemcial based Disinfectants. No staining, No stickiness, No BPA, Plastics or Solvents.Unscented and Dye Free. All Natural ingredients.
  • Numeous other saftey studies including ingestion, injection, absorption, skin sensitivity, cytotoxicity and irritation.
  • Effectively used to rehydrate Bone Allograft particulate and Collagen Membrane.

* Consensus on Wound Antisepsis: Update 2018, Axel Kramer et al. Skin Pharmacol Physiol 2018;31:28–58 DOI 10.1159/000481545

** Bactericidal activity of combinations of Silver–Water DispersionTM with 19 antibiotics against seven microbial strains. Souze,Mehta and Leavitt. Current Science, Vol. 91, Nos.7, pp 926-9, 10 October 2006

NOTE: Use of the this Wound wash Irrigant can be followed with the application of the OraSIL™ Wound Healing, Disinfectant HydroGel to help create a protective barrier and additonal antimicrobial, wound healing benefit.

a) THE SCIENCE: The crystalline lattice shell which surrounds the solid Nanometallic core of our OraSIL™ product (according to Scanning Electron Micrograph Scans “SEMs”) contains up to 20,000 highly charged multivalent particles on its surface (See Science of Nanotechnology Section). This provides for a brut force, attack on surrounding microoganisms and is why the OraSIL Nanoparticle is so highly effective at killing bacteria.  Comparing NanoSilver to Ionic Silver is like comparing a ‘gattling gun’ to a ‘pea shooter’. Remember that when you are dealing with ionic silver you are dealing with “one and done” – when you are dealing with OraSIL you are dealing with a sustained brut force attack. There are also several other modes of action which makes the OraSIL™ Wound Wash Irrigant with 10ppm NanoSilver a superior wound healing, disinfectant. Our NanoSilver also has a patented resonance frequency (similar to that of UV light) which is deadly to a diverse array of microorganisms.  In water, our NanoSilver particles and their highly electro-active oxide layer share electrons with the hydrogen bonds of the Oxygen and Hydrogen atoms, creating what is defined in the peer reviewed literature as “Structured Water”. This Structured Water creates the ability to ‘electrify’ the water particles which creates a phenomenon called High Energy Nanosonic Dynamic Dispersion Field or HENDDF. HENDDF creates the ability to eliminate polymicrobial biofilms as has been further evidenced in several peer reviewed / published research papers.

Until the development of the OraSIL™ Wound Wash Irrigant 10ppm products with ‘wound healing’ and ‘disinfectant’ benefits had remained mutally exclusive and simply did not exist…..

     For further details please visit the “Science of Nanotechnology” section.

b) COMPLETE INGREDIENT LIST FOR ORASIL WOUND WASH IRRIGANCT 10PPM

Primary / Sole Ingredient: 10 ppm NanoSilver (Purified Silver in Deionized Water)

c) OPTIMAL VISCOSITY  OraSIL™ Wound Wash Irrigant 10ppm has been formulated as a liquid with the consistency and hydrophilicity of saline so it is capable of washing over and penetrating  underneath a periodontal flap or into a boney osteotomy site. It is equally effective when used as a hydrating solution to rehydrate bone allograft or resorbable collagen membranes.- Perfect for any type of surgery in any part of the mouth as an antimicrobial wound irrigant. Likewise, the OraSIL™ Wound Wash Irrigant 10ppm can be used to help flush out and irrigate non healing, infected wounds or granulation tissue, commonly encountered with a dry socket or around an surgical incision for an apicoectomy/retrofill. OraSIL™ Wound Wash Irrigant 10ppm can also be used to clean and remove the BioFilm and any materia alba/plaque from a dirty denture or ortho retainer, mouthguard, CAT, MAD or orthotic.  These appliances can also be soaked and stored in the OraSIL™ Wound Wash Irrigant 10ppm. The OraSIL™ Wound Wash Irrigant 10ppm can be applied as many times as is required as it is basically purified water and therefore safe and non toxic when ingested. After you have irrigated the surgical site with OraSIL™ Wound Wash Irrigant 10ppm you can apply the OraSIL Wound Healing Hydrogel™ for extended protection and anti-inflammatory, pain relief.

The Worlds FIRST WOUND WASH IRRIGANT containing NanoSilver capable of specifically targeting and killing pathogenic bacteria yeast and fungi and removing smear layers and biofilms and allowing for natural healing.

Call today or Click HERE for your Free Sample of OraSIL™ Wound Wash Irrigant 10ppm. Once you’ve tried our Wound Wash Irrigant- you will see why Dentists are switching to OraSIL™.

Description: OraSIL™ Wound Wash Irrigant 10ppm  is a water based silver solution in ultra-pure water with the same consistency of Normal Saline – but it acts like a Super-oxidized water with powerful antimicrobial capabilities.  OraSIL™ Wound Wash Irrigant 10ppm is recognized as an FDA USP 51 Antimicrobial Preservative and does not burn, stain or leave a sticky residue. This Wound wash irrigant contains no glycerin or petroleum by products. Indications for Use: Used to help heal and disinfect surgerized tissues and or infected wounds/surgical sites in the mouth  Can be used to clean and disinfect partial and complete dentures and other medical devices including CAT trays, retainers, mouthguards and orthotics. Directions for Use: 1. Bottle of Wound Wash Irrigant (Figure 1) a.Open bottle cap. b. Pull back on plunger handle of Monoject syringe, suctioning up Wound Wash Irrigant solution. c.Verify the consistency and color of the product before applying to device or surgical site. OraSIL™ Wound Wash Irrigant 10ppm can be reapplied to the surgical site multiple times daily until it has been throughly cleaned.  Precautions and Warnings: 1.Carefully read and understand all instructions before using. 2.Keep out of reach of children. 3. If product comes in contact with the eyes – Do nothing as this solution is nothing more than purifed water. 4. Store at room temperature. 5.Do not use after expiration date noted on container. NOTE: For additional information about using OraSIL™ Wound Wash Irrigant 10ppm please go to DDSource.com

a) CLINICAL DATA: Extensive Clinical (in-vivo) and Laboratory (in-vitro) documentation has confirmed that the OraSIL™ Wound Wash Irrigant 10ppm is highly effective at disinfecting a surgical site and reducing post op. pain and inflammation. Published studies have clearly demonstrated the ability of the NanoSilver Gel to kill oral bacteria and 100% of their associated biofilms including the 3 most common oral bacteria – Strep. mutans, Strep. salivarius and Strep. sanguis* There is no need to remove the excess OraSIL™ Wound Wash Irrigant 10ppm from the wound as it is basically purified water and therefore safe and non toxic when ingested.

* Please refer to Scientific Articles section below for full copy of the attached research article entitled “Efficacy of a Silver Colloidal Gel on Oral Bacteria In vitro” by Reid et al.

b) SCIENTIFIC ARTICLES / PUBLICATIONS

1. “Bactericidal activity of combinations of Silver–Water DispersionTM with 19 an tibiotics against seven microbial strains” De Souza,Mehta and Leavitt, Current Sci ence Vol 91, Nos. 7, Oct 10,2006]

2. “Silver Sol improves wound healing: Case studies in the use of Silver Sol in clos ing wounds (including MRSA), preventing infection, inflammation and activating stem cells”. Moeller and Pederson, Journal of Scientific Outcomes – JSHO. Vol 1., July 4, 2009.

3. Silver NanoParticles in Dentistry –  A review of 155 peer reviewed articles, Volume 33, Issue 10, October 2017, Pages 1110-1126.

4. Efficacy of a Silver Colloidal Gel on Oral Bacteria In vitro by Ted W Reid et al.  US National Library of Medicine. Version 1. F1000Res. 2019; 8: 267. Published online 2019 Mar 7. doi: 10.12688/f1000research.17707.1

5. “The Next Generation of Wound Care” – A White Paper on SilvrSTAT, Dr. Cynthia Eaton.

6. “A Novel Non Surgical Periodontal Protocol for Treating Refractory Periodontitis  utilizing Nano Metallic Silver Tetrahedal Tetraoxide”. A White Paper on the Den- tal uses of OraSIL Wound Wash Irrigant 10ppm and OraSIL Wound Healing Hydrogel 32ppm. Dr. Andrew Willoughby, DMD et al. 2017.

The Safety and Efficacy of this specific NanoSilver technology was re-confirmed in 2018, when it was tested in the worlds largest Human Ingestion and Saftey study on NanoSilver.  The results confirmed that this NanoSIlver was safe and non toxic when ingested, inhaled and or adsorbed and was published as a 3 part clinical report in PubMED.  It was also a cited reference in the worlds largest and most recent Meta Analysis on NanoSilver particles in Dentistry which appeared in 2018 in the Journal of Dental Materials ( See Research Appendices tab in “Science of Nanotechnology Section”).

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